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- • The vast majority of women with invasive vulvar carcinoma are postmenopausal. But there has been a definite
- trend over the past two decades of an increasing incidence of carcinoma in situ and invasive squamous cell
- carcinoma in younger women. Forty percent of women with carcinoma in situ are under 40 years old.
- • Five to ten percent of women with invasive vulvar carcinoma have a history of genital warts, and 15 percent
- have a history of or subsequent diagnosis of a cancer confined to the skin (carcinoma in situ) or invasive
- carcinoma of the cervix .
- • Approximately 80 percent of the invasive squamous lesions of the vulva are associated with human papilloma
- virus types 16 or 18.
- • Other sexually transmitted diseases such as syphilis, lymphogranuloma venereum and herpes simplex virus II
- also increase the risk for vulvar carcinoma.
- • There is a higher incidence in women from lower socioeconomic groups, women with multiple partners and
- women with a history of infectious vulvitis or a history of vulvar dystrophy (abnormal benign or premalignant
- skin changes).
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